Hydrochloric Acid → HCID 21192919, compound

Participants

Reaction Steps

N-(8-Methyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxy-3-trifluoromethylbenzamide (0.15 g) in methanol: 2N sodium hydroxide (15 ml 2:1) was stirred at room temperature for 1 h. 2M hydrochloric acid (4.5 ml) was added and solvent (10 ml) removed at reduced pressure. The residual solvent was extracted with dichloromethane, the organic phase washed with brine, dried MgSO4) and solvent removed at reduced pressure to give N-(8-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxy-3-trifluoromethylbenzamide (0.08 g)

Provenance & Evidence