2-Dimethylaminopyridine → HCID 21192928, compound

Participants

Reaction Steps

Formic acetic anhydride (0.21 g) was added to N-(8-chloro-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-methoxy-3-trifluoromethylbenzamide (0.15 g) and dimethylaminopyridine (0.05 g) in dichloromethane. The mixture was stirred at room temperature overnight and quenched with saturated aqueous sodium hydrogen carbonate (20 ml). The organic phase was separated and washed with brine, dried (MgSO4) and solvent removed at reduced pressure. The residue was column chromatographed (silica gel, ammonia/methanol/dichloromethane mixtures as eluant) to give the title compound (0.10 g)

Provenance & Evidence