反应详情

The title compound was prepared according to the procedure in Example 5, step 2 using 2′-methoxy-[1,1′;3′,1″]terphenyl-5′-carboxylic acid (1.031 g, 3.388 mmol), oxalyl chloride (0.325 mL, 3.727 mmol), commercial 2-ethylbenzofuran (0.4953 g, 3.388 mmol) and tin (IV) chloride (0.436 mL, 3.727 mmol) in CH2Cl2. Purification on Biotage KP-Sil eluting with 3% EtOAc/ pet. ether gave 1.070 g, (73%) of the tide compound. 1H NMR (DMSO-d6) δ1.24 (t, 3H), 2.90 (quartet, 2H), 3.21 (s, 3H), 7.30-7.67 (m, 14H), 7.75 (s, 2H).

1. customPurification on Biotage KP-Sil
2. washeluting with 3% EtOAc/ pet. ether