Boron tribromide dichloromethane → HCID 131721939, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 5, step 3 using (2-benzyl-4,5-dimethyl-thiophen-3-yl)-(5-methyl-6-methoxy-biphen-3-yl)-methanone (1.68 g, 4.09 mmol) and 1M boron tribromide/CH2Cl2 (8.58 mL). Purification on Biotage KP-Sil eluting with 15% acetone/hexane gave 1.29 g (80%) of the title compound. 1H NMR (DMSO-d6) δ1.83 (s, 3H), 2.17 (s, 3H), 2.25 (s, 3H), 3.85 (s, 2H), 7.07-7.10 (m, 2H), 7.14-7.26 (m, 3H), 7.33-7.43 (m, 6H), 7.54 (d, 1H), 9.31 (s, 1H).

Provenance & Evidence