反应详情

The title compound was prepared according to the procedure in Example 5, step 3 using [2-(4-bromo-benzyl)-4,5-dimethyl-furan-3-yl]-(3,5-diisopropyl-4-methoxy-phenyl)-methanone (1.61 g, 3.32 mmol) and 1M boron tribromide/CH2Cl2 (6.97 mL) in CH2Cl2. Purification on Biotage KP-Sil eluting with 15% acetone/hexane gave 1.37 g (88%) of the title compound. 1H NMR (DMSO-d6) δ1.12 (d, 12H), 1.78 (s, 3H), 2.17 (s, 3H), 3.30 (septet, 2H), 3.81 (s, 2H), 7.01 (dd, 2H), 7.40 (s, 2H), 7.42 (d, 2H), 9.10 (s, 1H). IR (KBr) 3400, 2950, 1640, 1580 and 1310 cm−1. mass spectrum (EI) m/z 468 (M+). Anal. Calcd. for C26H29BrO3: C, 66.53; H, 6.23; N, 0.00. Found: C, 66.57; H, 6.39; N, 0.05.

1. customThe title compound was prepared
2. customPurification on Biotage KP-Sil
3. washeluting with 15% acetone/hexane