反应详情

The title compound was prepared according to the procedure in Example 5, step 3 using (2-benzyl-4,5-dimethyl-thiophen-3-yl)-(3-cyclopentyl-4-methoxy-phenyl)-methanone (3.32 g, 8.20 mmol) and 1M boron tribromide/CH2Cl2 (1.6 mL) in CH2Cl2. Purification on Biotage KP-Sil eluting with a 2, 5 & 10% EtOAc/hexane step gradient gave 0.63 g (18%) of the title compound. 1H NMR (DMSO-d6) δ consistent.

1. customThe title compound was prepared
2. customPurification on Biotage KP-Sil
3. washeluting with a 2, 5 & 10% EtOAc/hexane step gradient