3,3-Diphenylpropyl iodide → [[2-(3,3-Diphenylpropyl)thio-4,5-dihydronaphtho[1,2-d]thiazol-7-yl]oxy]acetic acid

HRID 1067429Notes

Reaction equation

HRID 1067429 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:18](=[CH:19][CH:20]=1)[C:13]1[N:14]=[C:15]([SH:17])[S:16][C:12]=1[CH2:11][CH2:10]2)C.[C:22]1([CH:28]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:29][CH2:30]I)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([CH:28]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:29][CH2:30][S:17][C:15]2[S:16][C:12]3[CH2:11][CH2:10][C:9]4[C:18](=[CH:19][CH:20]=[C:7]([O:6][CH2:5][C:4]([OH:3])=[O:21])[CH:8]=4)[C:13]=3[N:14]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 155128783,3-Diphenylpropyl iodideHCID 178472938HCID 178472938, compound

Product 1

HCID 70117519[[2-(3,3-Diphenylpropyl)thio-4,5-dihydronaphtho[1,2-d]thiazol-7-yl]oxy]acetic acidYield 54%

Procedure

Using ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-7-yl)oxy]acetate and 3,3-diphenylpropyl iodide, the procedure of Example 1 was otherwise repeated to synthesize the title compound. Yield 54%.

Sources & evidence

ORD record
ord-9ece1e9757044e9694764881399356e7
Source dataset
uspto-grants-2001_06
Patent number
US06248766B1

Reaction notes

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