Diphenylmethane bromide → [(2-Diphenylmethylthio-8H-indeno[1,2-d]thiazol-7-yl)oxy]acetic acid

HRID 1067442Notes

Reaction equation

C([O:3][C:4](=[O:20])[CH2:5][O:6][C:7]1[C:8]2[CH2:9][C:10]3[S:14][C:13]([SH:15])=[N:12][C:11]=3[C:16]=2[CH:17]=[CH:18][CH:19]=1)C.[Br-].[C:22]1([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([CH:28]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[S:15][C:13]2[S:14][C:10]3[CH2:9][C:8]4[C:7]([O:6][CH2:5][C:4]([OH:3])=[O:20])=[CH:19][CH:18]=[CH:17][C:16]=4[C:11]=3[N:12]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

Reactant 2

HCID 18470978Diphenylmethane bromide

HCID 178472950HCID 178472950, compound

Product 1

HCID 18470996[(2-Diphenylmethylthio-8H-indeno[1,2-d]thiazol-7-yl)oxy]acetic acidYield 61%

Procedure

Using ethyl[(2-mercapto-8H-indeno[1,2-d]thiazol-7-yl)oxy]acetate and diphenylmethane bromide, the procedure of Example 21 was otherwise repeated to synthesize the title compound. Yield 61%.

Sources & evidence

ORD record: ord-10843bf05b934262b86fc1abafae7f32
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06248766B1

Reaction notes

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