Acetamide, 2,2-diphenylthio- → [(2-Diphenylmethyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acid

HRID 1067454Notes

Reaction equation

HRID 1067454 reaction equation
C([O:3][C:4](=[O:19])[CH2:5][O:6][C:7]1[C:16]2[CH2:15][CH2:14][CH:13](Br)[C:12](=O)[C:11]=2[CH:10]=[CH:9][CH:8]=1)C.[C:20]1([CH:26]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:27]([NH2:29])=[S:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([CH:26]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:27]2[S:28][C:13]3[CH2:14][CH2:15][C:16]4[C:11](=[CH:10][CH:9]=[CH:8][C:7]=4[O:6][CH2:5][C:4]([OH:3])=[O:19])[C:12]=3[N:29]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 2734828Acetamide, 2,2-diphenylthio-HCID 21193655Ethyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate

Product 1

HCID 18471097[(2-Diphenylmethyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic acidYield 31%

Procedure

Using ethyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate and diphenylthioacetamide, the procedure of Example 52 was otherwise repeated to synthesize the title compound. Yield 31%. Amorphous solid.

Sources & evidence

ORD record
ord-5ca57a0197094b038d5ca99d27928113
Source dataset
uspto-grants-2001_06
Patent number
US06248766B1

Reaction notes

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