2,2-Diphenylethyl iodide → [(2-(2,2-Diphenylethyl)thio-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetic acid

HRID 1067458Notes

Reaction equation

HRID 1067458 reaction equation
C([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:20]=[C:19]2[C:10]([CH2:11][CH2:12][C:13]3[S:17][C:16]([SH:18])=[N:15][C:14]=32)=[CH:9][CH:8]=1)C.[C:22]1([CH:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:29]I)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([CH:28]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:29][S:18][C:16]2[S:17][C:13]3[CH2:12][CH2:11][C:10]4[C:19](=[CH:20][C:7]([O:6][CH2:5][C:4]([OH:3])=[O:21])=[CH:8][CH:9]=4)[C:14]=3[N:15]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 184709932,2-Diphenylethyl iodideHCID 178472936HCID 178472936, compound

Product 1

HCID 18470977[(2-(2,2-Diphenylethyl)thio-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetic acidYield 69%

Procedure

Using ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetate and 2,2-diphenylethyl iodide, the procedure of Example 21 was otherwise repeated to synthesize the title compound. Yield 69%.

Sources & evidence

ORD record
ord-37be38d8bf634e53b12f16cd19842b8f
Source dataset
uspto-grants-2001_06
Patent number
US06248766B1

Reaction notes

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