3-Methoxyphenyl isocyanate → HCID 22243797, compound

HRID 1067489Notes

Reaction equation

HRID 1067489 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:5]=[CH:4][N:3]=1.[CH3:21][O:22][C:23]1[CH:24]=[C:25]([N:29]=[C:30]=[O:31])[CH:26]=[CH:27][CH:28]=1>ClCCl>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:10]2[CH:9]=[CH:8][CH:7]=[C:6]3[C:11]=2[C:2]([NH:1][C:30]([NH:29][C:25]2[CH:26]=[CH:27][CH:28]=[C:23]([O:22][CH3:21])[CH:24]=2)=[O:31])=[N:3][CH:4]=[N:5]3)=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 878433-Methoxyphenyl isocyanateHCID 22386590HCID 22386590, compound

Product 1

HCID 22243797HCID 22243797, compoundYield 74.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Amino-5-(4-methoxyphenoxy)quinazoline (0.35 g, 1.3 mmol) and 3-methoxyphenyl isocyanate (0.23 g, 1.6 mmol) were reacted in 20 ml of dichloromethane according to procedure E to give 1-[5-(4-methoxyphenoxy)quinazolin-4-yl]-3-(3-methoxyphenyl)urea (0.4 g, 74.1%, m. p. 209-210° C.).

Sources & evidence

ORD record
ord-a5d5e39975384dbe89fbeb94ca6150d5
Source dataset
uspto-grants-2001_06
Patent number
US06248771B1

Reaction notes

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