6-Chloro-7-t-butyl[1,2,4]triazolo[1,5-b]pyridazine → 7-t-Butyl-6-[2-[4-(Diphenylmethoxy)piperidino]ethoxy][1,2,4]triazolo[1,5-b]pyridazine

Participants

Reaction Steps

4-(Diphenylmethoxy)-1-piperidineethanol (740 mg) was dissolved in dried tetrahydrofurane (18 ml), followed by addition of sodium t-butoxide (251 mg). The mixture was refluxed under heating for 25 minutes. After the mixture was cooled, 7-tert-butyl-6-chloro[1,2,4]triazolo[1,5-b]pyridazine (501 mg) was added thereto. The mixture was refluxed under heating for 2 hours. After the mixture was cooled, ice-water was added thereto, followed by extraction with ethyl acetate. The extract was washed with an aqueous sodium chloride saturated solution, dried over magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica-gel column chromatography and eluted with ethyl acetate. Fractions containing the objective compound were collected and recrystalized from ethyl acetate to yield the title compound (380 mg).

Provenance & Evidence