Sodium Hydroxide → HCID 22989421, compound

Participants

Reaction Steps

482 mg of ethyl 2-[6-[4-[4-(diphenylmethyl)piperazino] butyl]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate was dissolved in 2 ml of ethanol; 1.8 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by thermal refluxing for 1 hour. After cooling, the mixture was concentrated under reduced pressure; the residue was diluted with water and ajusted to pH 5 by the addition of 1 N hydrochloric acid. Ethyl acetate was added to cause crystallization; the crystal precipitated was washed with water-acetone (2:1) and dried to yield 386 mg of the title compound.

Provenance & Evidence