HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1067653Generated: October 30, 2026
Benzene → N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide
https://huagongshe.com/reaction/1067653
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide | HCID 9950752 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide | HCID 18424394 | 89.6% |
Reaction Steps
A mixture of 92 mg of N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluorometyl-2H-1-benzopyran-4-carbamide, 60 mg of Lawesson's reagent and 2 ml of benzene was stirred with heating at 80° C. for one hour. The reaction mixture was subjected to silica gel column chromatography (eluent:methylene chloride) to give 50 mg of N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide; m.p. 105-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06248777B1 |
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| Source dataset | uspto-grants-2001_06 |
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| ORD ID | ord-078aa06b3a21443998989cc5ffe860f0 |
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| Source note | uspto-grants-2001_06 |
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