Thionyl Chloride → HCID 178420286, compound

HRID 1067675Notes

Reaction equation

HRID 1067675 reaction equation
[Cl-].C1([C:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2C=CC=CC=2)N2C=C(CCC)N=C2)C=CC=CC=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:36]2[CH:40]=[C:39]([CH2:41][CH2:42][CH2:43][OH:44])[N:38]=[CH:37]2)C=CC=CC=1.S(Cl)(Cl)=O.C1(CC[O-])C=CC=CC=1.[Na+]>>[C:23]1([CH2:8][CH2:17][O:44][CH2:43][CH2:42][CH2:41][C:39]2[N:38]=[CH:37][NH:36][CH:40]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

5

Reactant 4

HCID 24386Thionyl ChlorideHCID 108328403-(1-Trityl-1H-imidazol-4-YL)propan-1-OLHCID 21193539HCID 21193539, compoundHCID 23699082HCID 23699082, compound

Product 1

HCID 178420286HCID 178420286, compound

Procedure

5 mmol of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propane chloride, prepared from 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanol with thionyl chloride, and 15 mmol of sodium 2-phenylethanolate are treated as described in Example 5.

Workup

  1. additionare treated

Sources & evidence

ORD record
ord-5a5ef28f47e040f6a9f640b0a4b239b0
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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