3-(1-Trityl-1H-imidazol-4-YL)propan-1-OL → HCID 178447039, compound

HRID 1067706Notes

Reaction equation

HRID 1067706 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15]O)[N:10]=[CH:9]2)C=CC=CC=1.[OH:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37](=[O:42])[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:32][CH:31]=1>>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][O:29][C:30]2[CH:31]=[CH:32][C:33]([CH2:36][C:37](=[O:42])[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:34][CH:35]=2)[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 108328403-(1-Trityl-1H-imidazol-4-YL)propan-1-OLHCID 22412575HCID 22412575, compound

Product 1

HCID 178447039HCID 178447039, compound

Procedure

5 mmol of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanol and 6 mmol of (4-hydroxyphenyl)hexanone (prepared from hexanoic acid according to standard methods (Friedel-Crafts acylation)) are treated as described in Example 56.

Sources & evidence

ORD record
ord-47fb298bf32049b2982eb4a3ee745b46
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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