Ethylene Glycol → HCID 178520159, compound

Participants

Reaction Steps

1.3 mmol of cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl ketone (Example 61) and a catalytic amount of 4-toluenesulphonic acid in 15 ml of ethylene glycol are brought to reflux for 5 hours. The solvent is evaporated off under reduced pressure, and the residue is dissolved in 10 ml of H2O and alkalized with ammonia. The crude product is extracted with dichloromethane and purified by rotatory chromatography (eluent: dichloromethane/methanol (99:1-90:10), ammoniacal atmosphere). The product is crystallized in the form of hydrogen maleate from diethyl ether and ethanol.

Provenance & Evidence