2'-Fluoro-4'-hydroxyacetophenone → HCID 178466795, compound

HRID 1067711Notes

Reaction equation

HRID 1067711 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][OH:16])[N:10]=[CH:9]2)C=CC=CC=1.[F:29][C:30]1[CH:35]=[C:34](O)[CH:33]=[CH:32][C:31]=1[C:37](=[O:39])[CH3:38]>>[F:29][C:30]1[CH:35]=[C:34]([O:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)[CH:33]=[CH:32][C:31]=1[C:37](=[O:39])[CH3:38]

Participants

3

Reactant 2

HCID 27249122'-Fluoro-4'-hydroxyacetophenoneHCID 108328403-(1-Trityl-1H-imidazol-4-YL)propan-1-OL

Product 1

HCID 178466795HCID 178466795, compound

Procedure

5 mmol of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanol and 6 mmol of (2-fluoro-4-hydroxyphenyl)ethanone are treated as described in Example 56.

Sources & evidence

ORD record
ord-2b5470ab57bd44868cfcdedc40f5c52e
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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