2,4-Difluorophenylacetone → HCID 178467619, compound

HRID 1067712Notes

Reaction equation

HRID 1067712 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][O-:16])[N:10]=[CH:9]2)C=CC=CC=1.[Na+].[F:30][C:31]1[CH:36]=[C:35](F)[CH:34]=[CH:33][C:32]=1[CH2:38][C:39](=[O:41])[CH3:40]>>[F:30][C:31]1[CH:36]=[C:35]([O:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)[CH:34]=[CH:33][C:32]=1[CH2:38][C:39](=[O:41])[CH3:40]

Participants

3

Reactant 2

HCID 27348812,4-DifluorophenylacetoneHCID 23682245sodium 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanolate

Product 1

HCID 178467619HCID 178467619, compound

Procedure

5 mmol of sodium 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanolate and 10 mmol of (2,4-difluorophenyl)propanone are treated as described in Example 61 (method A).

Sources & evidence

ORD record
ord-7dc542005ffc42a9b24cee1d1909d3f9
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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