3-(1-Trityl-1H-imidazol-4-YL)propan-1-OL → HCID 178432560, compound

HRID 1067715Notes

Reaction equation

HRID 1067715 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][OH:16])[N:10]=[CH:9]2)C=CC=CC=1.[CH3:29][C:30]1[O:34][N:33]=[C:32]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2O)[N:31]=1>>[CH3:29][C:30]1[O:34][N:33]=[C:32]([C:35]2[CH:40]=[CH:39][C:38]([O:16][CH2:15][CH2:14][CH2:13][C:11]3[N:10]=[CH:9][NH:8][CH:12]=3)=[CH:37][CH:36]=2)[N:31]=1

Participants

3

Reactant 2

HCID 108328403-(1-Trityl-1H-imidazol-4-YL)propan-1-OLHCID 13559054752561-90-7

Product 1

HCID 178432560HCID 178432560, compound

Procedure

5 mmol of 3-(1-triphenylmethyl-1H-imidazol-4-yl)propanol and 6 mmol of (5-methyl-1,2,4-oxadiazol-3-yl)phenol (prepared according to Swain, C. J. et al. J. Med. Chem. 1991, 34, 140) are treated as described in Example 56, but isolated in the form of the free base.

Workup

  1. customisolated in the form of the free base

Sources & evidence

ORD record
ord-cc9df159edef4e57bbc318021d5b1a3a
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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