4-((Trimethylsilyl)ethynyl)phenol → HCID 178504182, compound

HRID 1067724Notes

Reaction equation

HRID 1067724 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][OH:16])[N:10]=[CH:9]1)=O)(C)(C)C.[CH3:17][Si:18]([CH3:29])([CH3:28])[C:19]#[C:20][C:21]1[CH:26]=[CH:25][C:24](O)=[CH:23][CH:22]=1>>[CH3:28][Si:18]([CH3:17])([CH3:29])[C:19]#[C:20][C:21]1[CH:26]=[CH:25][C:24]([O:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 107502104-((Trimethylsilyl)ethynyl)phenolHCID 20253506tert-Butyl 4-(3-hydroxypropyl)-1H-imidazole-1-carboxylate

Product 1

HCID 178504182HCID 178504182, compound

Procedure

5 mmol of 4-(3-hydroxypropyl)-1H-imidazole-1-carboxylic acid tert-butyl ester and 5 mmol of 4-(2-(trimethylsilyl)-1-ethynyl)phenol (for the preparation see the literature mentioned in Example 122) are treated as described in Example 122.

Workup

  1. additionare treated

Sources & evidence

ORD record
ord-60232b37f8d34251ac14639d9bafe468
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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