Lithium Hydroxide → HCID 70158869, compound

Participants

Reaction Steps

Ketone of example 51 (60 mg, 0.086 mmol), THF (3 mL), and LiOH (0.3 mL, 1M in H2O, 0.34 mmol;) were combined and refluxed under N2 for 2 h. The THF was evaporated, the aqueous phase was extracted with CH2Cl2 (2×), and the combined organics were washed with brine and dried (Na2SO4) filtered and concentrated in vacuo. FCC (silica gel 1:4, EtOAc/hex) afforded the desired ketone (47 mg).

Provenance & Evidence