HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Methyl 1-[2-(2-tetrahydropyranyl)oxyethyl]-2-indolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 1H-indole-2-carboxylate | HCID 70992 | — |
| Reactant | 2H-Pyran, tetrahydro-2-(2-iodoethoxy)- | HCID 11118662 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1-[2-(2-tetrahydropyranyl)oxyethyl]-2-indolecarboxylate | HCID 21194121 | 83% |
Reaction Steps
The reaction was carried out in a manner similar to Reference Example 5 except for using 2.0 g (11.4 mmol) of methyl 2-indolecarboxylate, 0.55 g (13.7 mmol) of 60% sodium hydroxide, 3.63 g (13.7 mmol) of 2-(2-iodo-ethoxy)tetrahydropyran (prepared from 2-iodoethanol and 3,4-dihydro-2H-pyran) and 50 ml of dimethylformamide. Thus, 2.87 g (83.0%) of methyl 1-[2-(2-tetrahydro-pyranyl)oxyethyl]-2-indolecarboxylate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248772B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-0edb686bd6734f4384906e9a8a815c31 |
| Source note | uspto-grants-2001_06 |