HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate → Ethyl 7-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate | HCID 21194661 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 7-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate | HCID 21194312 | — |
Reaction Steps
The reaction was carried out in a manner similar to Reference Example 18 b) except for using 6.50 g (17.2 mmol) of ethyl 7-benzyloxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate, 1.0 g of 10% palladium/carbon and 150 ml of ethanol. Ethyl 7-hydroxy-1-methyl-4-trifluoromethyl-2-indolecarboxylate was thus obtained in the yield of 4.95 g (97.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248772B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-d26cff9d666e4c1d8a2ee96991a7e30a |
| Source note | uspto-grants-2001_06 |