HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → N-carbamimidoyl-1-methylindole-4-carboxamide;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Methyl 1-methyl-1H-indole-4-carboxylate | HCID 12396110 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-carbamimidoyl-1-methylindole-4-carboxamide;hydrochloride | HCID 178478911 | 66.1% |
Reaction Steps
The reaction was carried out in a manner similar to Example 1 except for using 0.85 g (4.49 mmol) of methyl 1-methyl-4-indolecarboxylate, 4.29 g (44.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.43 g (44.9 mmol) of sodium methoxide. Thus 0.75 g (66.1%) of 1-methyl-4-indoloylguanidine hydrochloride was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248772B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-2513c74fcf0c497d809e0b4d45e8f33d |
| Source note | uspto-grants-2001_06 |