HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → HCID 178485151, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Ethyl 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indolecarboxylate | HCID 21194089 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178485151 | HCID 178485151 | 47% |
Reaction Steps
The reaction was carried out in a manner similar to Example 186 b) except for using 0.45 g (1.32 mmol) of ethyl 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indolecarboxylate, 2.52 g (26.4 mmol) of guanidine hydrochloride, 1.42 g (26.4 mmol) of sodium methoxide and 25 ml of methanol. Thus, 0.24 g (47.0%) of 4-chloro-1-methyl-6-(4-nitrophenoxy)-2-indoloylguanidine was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248772B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-b5139db4c27f45e58089829211c416f9 |
| Source note | uspto-grants-2001_06 |