HCID 21195131, compound → HCID 21195133, compound

HRID 1067887Notes

Reaction equation

HRID 1067887 reaction equation
[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[CH:12]=[C:11]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:10]=2)[CH:6]=[CH:5][CH:4]=1)#[N:2]>C(O)(=O)C.[Pd]>[NH2:2][CH2:1][C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[CH:12]=[C:11]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:10]=2)[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 21195131HCID 21195131, compound

Product 1

HCID 21195133HCID 21195133, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 6-cyano-4′-(4-methoxyphenyl)-2,2′:6′,2″-terpyridine (4 mmol) and 480 mg of 10% Pd/C in 130 ml of acetic acid is hydrogenated (H2, 50 psi) at 45° C. for 22 hours. The reaction mixture is filtered and the solvent is stripped, the residue is triturated with methanol, filtered and dried to provide the desired product as the acetic acid salt.

Workup

  1. customat 45° C.
  2. customfor 22 hours
  3. filtrationThe reaction mixture is filtered
  4. customthe residue is triturated with methanol
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-b3dd37e2777f47cebaa1d6ad9460b616
Source dataset
uspto-grants-2001_06
Patent number
US06248870B1

Reaction notes

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