Diethyl Sulfate → HCID 54386540, compound

Participants

Reaction Steps

A mixture of tert-butylisopropylamine (11.5 g, 0.1 mol) and diethyl sulfate (15.42 g, 0.1 mol) was refluxed for 2 h. Aqueous 8 M potassium hydroxide (20 ml, 0.16 mol) was added and the organic layer was separated. The aqueous layer was extracted with n-pentane (20 ml). The organic solutions were combined, dried over magnesium sulfate, and the product was isolated by distillation: 7.16 g, (50%), bp 140-142° C.; 1H NMR (CDCl3) δ0.99 (m, J=6.2 Hz, 9H, CH3), 1.10 (s, 9H, CH3), 2.55 (q, J=6.2 Hz, 2H, CH2, 3.35 (septet, J=6.2, 1H, CH).

Provenance & Evidence