Cyclohexylamine → HCID 22617106, compound

Participants

Reaction Steps

In an autoclave, 2.04 g of methyl N′-dipropoxymethylenehydrazinecarboxylate (8.9 mmol) and 3.23 g of cyclohexylamine (32.2 mmol) were initially charged in 25.8 g of methanol. After 5 hours at 110° C., the solvent was distilled off and the crude 4-methyl-5-cyclohexyloxy-2,4-dihydro-1,2,4-triazol-3-one (1.3 g) was purified by column chromatography (mobile phase: ethyl acetate). This gave 0.37 g (18%) of pure product. Melting point: 132-136° C.

Provenance & Evidence