Water → tert-butyl 2-[3-{[(4-chlorobenzyl)amino]carbonyl}-6-iodo-4-oxo-1(4H)-quinolinyl]acetate

Participants

Reaction Steps

To a flask containing N-(4-chlorobenzyl)-6-iodo-4-hydoxy-3-quinolinecarboxamide (0.22 g) obtained as described in Preparation No. 4 in DMF (5 mL) is added potassium carbonate (0.21 g) and tert-butylbromoacetate (0.11 mL). After stirring overnight, the reaction is diluted with dichloromethane and partioned against water. The organic phase is washed with brine, dried over sodium sulfate, concentrated under reduced pressure, and dried in vacuo to give 0.26 g of the title compound as a white solid.

Provenance & Evidence