4-Chlorobenzylamine → HCID 21192514, compound

Participants

Reaction Conditions

Reaction Steps

To a flask containing ethyl 6-[[2-(acetyloxy)ethyl](ethyl)amino]-1-methyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate from Preparation No. 16 (0.22 g) is added p-chlorobenzylamine (1.0 mL). The reaction is tightly capped and heated to 190° C. overnight. The reaction is cooled to room temperature. The residue is adsorbed onto silica and chromatographed on silica eluting with 4% to 8% methanol in dichloromethane. The product-containing fractions are evaporated to give 0.12 g of the title compound as a off-white solid.

Provenance & Evidence