Diethyl (ethoxymethylene)malonate → HCID 178469653, compound

Participants

Reaction Steps

A solution of 2-iodoaniline (8.22 g) and diethyl ethoxymethylenemalonate (8.00 mL) is heated at 130° C. for 1 h. The reaction is cooled to room temperature. Diphenyl ether (100 mL) is added and the reaction is heated at 250° C. for 1.25 h. The reaction is cooled to room temperature and the resulting solid is filtered, washed thoroughly with hexanes, and dried to give ethyl 4-hydroxy-8-iodo-3-quinolinecarboxylate (6.84 g).

Provenance & Evidence