4-Chlorobenzylamine → HCID 178522858, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 4-hydroxy-6-(tetrahydro-2H-pyran-4-ylmethyl)-3-quinolinecarboxylate (0.315 g) from Preparation No. 51 and 4-chlorobenzylamine (0.61 nL) is heated to 180° C. for 1 h. The reaction mixture is cooled to 65° C. and diluted with CH2Cl2. Hexanes are added to initiate precipitation of the product. The resulting solid is collected and dried to yield 0.33 g of N-(4-chlorobenzyl)-4-hydroxy-6-(tetrahydro-2H-pyran-4-ylmethyl)-3-quinolinecarboxamide as an off-white solid.

Provenance & Evidence