反应详情

温度

190 °C

A flask containing ethyl 6-(4-morpholinylmethyl)-4-oxo-1-tetrahydro-2H-pyran-4-yl-1,4-dihydro-3-quinolinecarboxylate (0.21 g) is treated with 4-chlorobenzylamine (2.0 mL). The reaction is tightly capped and heated to 190° C. for 1 hour. The reaction is cooled to room temperature, adsorbed onto silica and chromatographed on silica eluting with 2% to 6% methanol in dichloromethane and then by recrystallization from ethyl acetate to afford 0.14 g of the title compound.

1. customThe reaction is tightly capped
2. temperatureThe reaction is cooled to room temperature
3. customchromatographed on silica eluting with 2% to 6% methanol in dichloromethane
4. customby recrystallization from ethyl acetate