反应详情

温度

190 °C

Ethyl 1-(4-morpholinyl)-6-(4-morpholinylmethyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylate (5.0 g) from Preparation No. 56 and 4-chlorobenzylamine (7.6 mL) are combined and heated to 190° C. for 7 hours. After cooling to room temperature, the mixture solidifies. The solid is triturated with a 10:1 mixture of EtOAc/MTBE (30 mL) and filtered on a frit. The crude solid is triturated again, this time with a hot mixture of 10:1 EtOAc/MTBE (110 mL). The suspension is cooled to room temperature and filtered on a frit to afford 4.9 g (79%) of the title compound as a white solid.

1. temperatureAfter cooling to room temperature
2. customThe solid is triturated with a 10:1 mixture of EtOAc/MTBE (30 mL)
3. filtrationfiltered on a frit
4. customThe crude solid is triturated again
5. additionthis time with a hot mixture of 10:1 EtOAc/MTBE (110 mL)
6. temperatureThe suspension is cooled to room temperature
7. filtrationfiltered on a frit