HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl alcohol → HCID 490484, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl alcohol | HCID 7859 | — |
| Reactant | HCID 21192582 | HCID 21192582 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | HCID 490484 | HCID 490484 | — |
Reaction Steps
1-Amino-N-(4-chlorobenzyl)-6-iodo-4-oxo-1,4-dihydro-3-quinolinecarboxamide (0.25 g) from Preparation No. 57, copper (I) iodide (32 mg), and bis(triphenylphosphine)palladium (II) chloride (19 mg) are suspended in diethylamine (8 mL). Propargyl alcohol (39 μL) is added and the mixture is allowed to stir at room temperature for 16 h. The mixture is diluted with ethanol and then concentrated in vacuo. The crude solid is triturated with dichloromethane and recrystallized in acetic acid to affording 76 mg of the title compound as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248739B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-d2e24624b39a4e4cbd87d6ec85726602 |
| Source note | uspto-grants-2001_06 |