HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 10507563, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | HCID 10791549 | HCID 10791549 | — |
| Reactant | (2S,9R)-2-Amino-11-[(benzyloxycarbonyl)amino]-7-(carbobenzyloxy)-9-(tetrahydropyran-2-yloxy)-7-azaundecanoic Acid | HCID 10841069 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 10507563 | HCID 10507563 | 58% |
Reaction Steps
According to the method described for the preparation of 18a, 17b (37 mg, 73.8 μmol) was reacted with trifluoroacetic acid (17 mg, 0.15 mmol) and 3,4-dihydro-2H-pyran (46 mg, 50 μL, 0.55 mmol) in CH2Cl2 (2 mL) to give 18b (25 mg, 58%) as a colorless oil: 1H NMR δ 1.26-1.96 (m, 14H), 3.02-4.04 (m, 10H), 4.32-4.63 (m, 1H), 5.06 (s, 2H), 5.11 (s br, 2H), 7.22-7.40 (m, 10H); HRMS m/z calcd for C31H44N3O8 586.3128, found 586.3137.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248866B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-6f39bd36bb2f4b7bac1704df3a19cd3f |
| Source note | uspto-grants-2001_06 |