Sodium Carbonate → HCID 20665002, compound

Participants

Reaction Steps

According to the method described for the preparation of 11a, 18b (26 mg, 44 μmol) was reacted with 9-fluorenylmethyl N-succinimidyl carbonate (22 mg, 66 μmol) and Na2CO3 (9 mg, 88 μmol) to give 11b (20 mg, 55%) as a colorless oil: 1H NMR δ 1.14-1.96 (m, 14H), 3.04-3.55 (m, 6H), 3.64-3.98 (m, 3H), 4.14 (m, 1H), 4.20 (t, 1H, J=6.9), 4.34 (d, 2H, J=6.9), 4.38-4.61 (m, 1H), 5.05 (s, 2H), 5.09 (s, 2H), 7.20-7.42 (m, 14H), 7.65 (m, 2H), 7.78 (d, 2H, J=7.4); HRMS m/z calcd for C46H54N3O10 808.3809, found 808.3839. Anal. calcd. for C46H53N3O10: C68.38, H 6.61, N 5.20. Found: C 68.26, H 6.69, N 5.13.

Provenance & Evidence