反应详情

To a solution of 1.4 g of 1-(4-(benzothiazol-2-yl)piperidin-1-yl)ethanone in 10 mL of MeOH was added 7.5 mL of KOH (45 wt. % solution). After refluxing for 18 hours, the reaction was cooled to room temperature. The mixture was partitioned between EtOAc and water. The organic phase was washed with brine and dried over MgSO4. Concentration under reduced pressure gave 540 mg of the title compound as a solid.

1. temperatureAfter refluxing for 18 hours
2. customThe mixture was partitioned between EtOAc and water
3. washThe organic phase was washed with brine
4. dry with materialdried over MgSO4
5. concentrationConcentration under reduced pressure