HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-piperidone → 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | 4-Fluorobenzene-1,2-diamine | HCID 164584 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine | HCID 21193065 | 5.9% |
Reaction Steps
The title compound was prepared from 750 mg 1-benzyl-4-piperidone, 1.0 g of 4-fluoro-benzene-1,2-diamine and 1.0 g sodium triacetoxyborohydride in 10 mL of THF, using a procedure analogous to that described in Example 95, Step A to provide 70 mg of the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248755B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-e51103e44a6a447387c2ef2dcae2561b |
| Source note | uspto-grants-2001_06 |