HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine | HCID 21193065 | — |
| Product | 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-1-H-benzoimidazole | HCID 21193025 | — |
Reaction Steps
The title compound was prepared from 170 mg of 1-N-(1-benzyl-piperidin-4-yl)-4-fluoro-benzene-1,2-diamine (from Step A), 7 mL of trimethyl orthoformate, and 0.2 mL of concentrated HCl, using a procedure analogous to that described in Example 95, Step B to provide 123 mg of the title compound as a viscous brown oil
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248755B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-e0952eeb83094009be8c674ee58813bd |
| Source note | uspto-grants-2001_06 |