(3R,4S)-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-phenylpyrrolidine → 2-(R)-(3-(S)-Formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(phenyl) propionic acid, benzyl ester

Participants

Reaction Steps

The title compound was prepared from 2-(R)-(3-(S)-hydroxymethyl-4-(S)-phenylpyrrolidin-1-yl)-2-(phenyl)propionic acid, benzyl ester (from Step B) using a procedure analogous to that described in preparation of Aldehyde 1. For the title compound: RF: 0.46 (4:1 v/v hexane/EtOAc); 1H NMR (300 MHz, CDCl3) δ1.73 (s, 3H), 2.95-3.10 (m, 3H), 3.33 (m, 1H), 3.50-3.63 (m, 2H), 5.25 (s, 2H), 7.12-7.38 (m, 15H), 9.62 (d, J=1.6 Hz).

Provenance & Evidence