4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine → alpha-(R)-(3-(S)-((4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester

Participants

Reaction Steps

When 0.070 g of 4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidine and 0.043 g of α-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester were used in the procedure of Example 124, Step C, there was obtained 0.061 g of α-(R)-(3-(S)-((4-(5-methyl-4-phenyl-1H-pyrazol-3(2H)-on-2-yl)-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester after chromatography on silica gel (20 mL column—elution with 3% MeOH in dichlormethane). ESI-MS 677.3 (M+H); TPLC A: 2.85 min.

Provenance & Evidence