Hydrochloric Acid → HCID 21193082, compound

Participants

Reaction Steps

Acetyl chloride (0.2 mL, 2.8 mmol) was added to 2 mL of methanol and stirred for 10 min. This solution of HCl in MeOH was added to 58 mg of 1-t-butyloxycarbonyl-4-(8,9-dihydro-7H-5-oxa-7-aza-benzocyclohepten-6-one-7-yl)-piperidine (Step A) and stirred for 2 hr. The reaction was concentrated in vacuo, the residue was diluted with EtOAc and the solution was concentrated again in vacuo leaving 46 mg of the title compound which was sufficiently pure for use in the next step. 1H NMR (500 MHz, CDCl3): δ2.06 (m, 2H), 2.35 (m, 2H), 3.02 (m, 4H), 3.5-3.8 (m, 4H), 4.35 (br s, 1H), 7.1-7.3 (m, 4H), 9.6 (br, 2H).

Provenance & Evidence