Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | tert-Butyl 4-carbamothioylpiperidine-1-carboxylate | HCID 2735648 | — |
| Reactant | 1-bromo-3-phenyl-2-propanone | HCID 11469927 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21193040 | HCID 21193040 | 34.1% |
Reaction Steps
To a solution of 65 mg of 1-bromo-3-phenyl-2-propanone (from reacting the acid chloride with diazomethane followed by hydrogen bromide) in 4 ml EtOH was added 74 mg of 1-boc-isonipecot-thioamide (from Step A). The reaction was stirred for 2 hours at 80° C. The solvent was then evaporated under reduced pressure. The residue was purified by flash chromatography with 10% EtOAc in hexane to give 37 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06248755B1 |
|---|
| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-7528e78b9d624afa874fddc9ecb57700 |
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| Source note | uspto-grants-2001_06 |
|---|
