HCID 21193074, compound → HCID 20664070, compound

Participants

Reaction Steps

2-(R)-(2-Methyl-3-(R)-formyl-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-3-(cyclopropyl)propionic acid, benzyl ester (54 mg, 0.13 mmol, from Step D) and 4-(3-benzyl-1-ethyl-(1H-pyrazol-5-yl))piperidine trifluoroacetate (58 mg, 0.17 mmol, from Example 1, Step C) were reacted via the procedure described in Example 1, Steps D and E to afford 34.3 mg (46% yield) of the title compound. 1H NMR (400 MHz, CDCl3) δ0.04-0.11 (m, 1H), 0.14-0.20 (m, 1H), 0.41-0.49 (m, 1H), 0.51-0.57 (m, 1H), 0.68-0.75 (m, 1H), 1.23 (t, 3H), 1.63 (d, 3H), 1.80-2.10 (m, 6H), 2.65-2.78 (m, 1H), 2.84-2.98 (m 2H), 3.00-3.10 (m, 2H), 3.16-3.23 (m, 1H), 3.30-3.40 (m, 1H), 3.50-3.68 (m, 4H), 4.02 (s, 2H), 4.15-4.20 (m, 1H), 4.20-4.30 (m, 3H), 5.24 (d, 1H), 5.39 (d, 1H), 5.93 (s, 1H), 7.02-7.44 (m, 14 H); ESI-MS (M+H): 663.9; HPLC A: 2.04 min.

Provenance & Evidence