Potassium Hydroxide → HCID 53877860, compound

Participants

Reaction Steps

To a solution of 70 mg of 1-benzoyl-4-(imidazo[1,2-a]pyridin-2-yl)-piperidine (from Step A) in 4 mL of ethanol was added 1 mL of 45% KOH solution. The reaction was refluxed for 14 hours. After concentration, the mixture was partitioned between EtOAc and water. Aqueous layer was extracted with EtOAc (3×). The combined organic phase was washed with brine, dried over MgSO4 and concentrated to give 22 mg of the title compound as a viscous oil.

Provenance & Evidence