Trifluoroacetic acid → HCID 86757030, compound

Participants

Reaction Steps

The title compound was prepared from 19 mg of α-(R)-(3-(S)-((4-(imidazo[1,2-a]pyridin-2-yl)-piperidine-1-yl)methyl)-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-cyclobutylpropanoic acid, 4-methoxy-benzyl ester (from Step C), 2 mL of TFA and 0.2 mL of anisole, using a procedure analogous to that described in Example 235, Step D to provide 16 mg of the title compound as a foamy solid. 1H NMR (500 MHz, CD3OD): δ1.45-1.64 (m, 6H), 1.83-2.04 (m, 6H), 2.30(t, J=14.2 Hz, 3H), 2.68-3.85(m, 12H), 6.93 (t, J=6.3 Hz, 1H), 7.27 (d, J=6.7 Hz, 2H), 7.35 (t, J=6.7 Hz, 1H), 7.45 (dd, J=13.6, 6.3Hz, 1H), 7.49 (d, J=13.5 Hz, 1H), 7.67 (s, 1H), 8.38 (d, J=6.9 Hz, 1H). ESI-MS 505 (M+H); HPLC A 2.21 min.

Provenance & Evidence