2-Amino-5-bromopyridine → 1-(t-Butoxycarbonyl)-4-(6-bromo-imidazo[1,2-a]pyridin-3-yl)-piperidine

HRID 1068219Notes

Reaction equation

HRID 1068219 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][CH:19]([CH:22](Br)[CH:23]=O)[CH2:18][CH2:17]1)=[O:15])([CH3:12])([CH3:11])[CH3:10]>>[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][CH:19]([C:22]2[N:3]3[CH:4]=[C:5]([Br:8])[CH:6]=[CH:7][C:2]3=[N:1][CH:23]=2)[CH2:18][CH2:17]1)=[O:15])([CH3:12])([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 21912701tert-Butyl 4-(1-bromo-2-oxoethyl)piperidine-1-carboxylate

Product 1

HCID 211930311-(t-Butoxycarbonyl)-4-(6-bromo-imidazo[1,2-a]pyridin-3-yl)-piperidine

Procedure

The title compound was prepared from 2-amino-5-bromopyridine and 1-(t-butoxycarbonyl)-4-(1-bromo-2-oxoethyl)-piperidine (from Example 292, Step C) according to the general procedure described in Example 235, Step A.

Sources & evidence

ORD record
ord-a3b3cb170ffa42068979b1f42a14d175
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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