2-Amino-4-Methoxypyridine → 1-(t-Butoxycarbonyl)4-(7-methoxy-imidazo[1,2-a]pyridin-3-yl)piperidine

Participants

Reaction Steps

The title compound was prepared from 1-(t-butoxycarbonyl)-4-(1-bromo-2-oxoethyl)-piperidine (from Example 292, Step C) and 2-amino-4-methoxypyridine (prepared using procedures analogous to those described by R. J. Sundberg et al, Org. Preparations & Procedures Int. 1997, 29, (1), 117-122) using a procedure similar to that described in Example 235 Step A. 1H NMR (500 MHz, CDCl3): δ 1.50 (s, 9H), 1.63˜1.75 (m, 2H), 2.05 (br d, J=13 Hz, 2H), 2.85˜3.00 (br, 3H), 3.88 (s, 3H), 4.15˜4.35 (br, 2H), 6.58 (d, J=7.4 Hz, 1H), 6.93 (br s, 1H), 7.25 (br s, 1H), 7.79 (d, J=7.5 Hz, 1H).

Provenance & Evidence